Web11 Jun 2024 · It has been confirmed that rat Thy-1N is complement-dependent, particularly sublytic C5b-9-dependent. 9, 10 Our early studies have disclosed that sublytic C5b-9 stimulation in vitro can induce rat GMC proliferation and ECM secretion. 11, 12 But, the underlying mechanism of sublytic C5b-9-triggered GMC proliferative pathological changes … Web结论：Sublytic C5b-9能够诱导GMCs合成Tsp-1、TGF-β_1，促进GMCs增殖和ECM分泌，其ECM的分泌可能与Tsp-1、TGF-β_1的合成有一定的关系。 第二部分沉默Pi3-k／Akt基因对sublytic C5b-9促进GMCs合成Tsp-1，TGF-β_1及其细胞增殖和ECM分泌的影响 目的：从基因水平上探讨沉默磷脂酰肌醇3 ...

subtletyの意味 - goo辞書 英和和英

WebInhibitors Sublytic complement inhibits sTNF-a induced tumor cell necro- of PKCz and cdc2 kinases that use NCL as substrate efficiently inhib- sis ited binding of NCL to the CD59 promoter, thus causing reduced Lili Liu ∗ , Zhuoya Li, Michael Kirschfink expression of CD59 in G361 melanoma cells (expressing full-length REST), while no effect on CD59 expression … WebThis gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like ... bolton strid yorkshire

sublytic是什么意思，亚溶解翻译-生物医药大词典 - bioon.com

WebFigure 2 . IRF-1/6/8 expression both in vivo and in vitro as well as the roles of IRF-8 in CCL3/4 production in vitro. (A, B, D, E) The expression of IRF-1/6/8 in the renal tissues of Thy-1N rats (A and D) and in the GMCs exposed to sublytic C5b-9 (B and E) at different time points was examined by qPCR (A and B) and IB (D and E). Web1 Feb 2003 · The complement system consists of >30 proteins that interact in a carefully regulated manner to destroy invading bacteria and prevent the deposition of immune complexes in normal tissue. This complex system can be activated by diverse mechanisms proceeding through distinct pathways, yet all converge on a final common pathway in … Web16 Dec 2013 · The increased production of interleukin 6 (IL-6) and transforming growth factor β1 (TGF-β1) by glomerular mesangial cells (GMCs) in rat Thy-1 nephritis (Thy-1N), a model of human mesangioproliferative glomerulonephritis, is accompanied by sublytic C5b-9 deposition, but the mechanism of IL-6 and TGF-β1 upregulation in rat GMCs triggered by … bolton sustainability report