WebBackground: PTHLH/PTHrP. The parathyroid hormone-like hormone (PTHLH), also known as PTHrP, has been recognized in patients suffering from tumors associated with the … WebPTHLH / PTHRP parathyroid hormone-like hormone. Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary ...
Parathyroid Hormone 1 Receptor - an overview - ScienceDirect
WebMar 3, 2024 · PTHrP is a key mediator of the actions of PTH on breast cancer cell migration. PTHrP (encoded by Pthlh) is a key mediator of the bone–breast vicious cycle, and treatment with intermittent PTH significantly decreased Pthlh expression in Cont-4T1 primary tumors while increasing the expression of Pthlh in Pth1rKD-4T1 primary tumors (Figure 6A). WebDescription. PTHRP antibody LS-B6787 is an unconjugated rabbit polyclonal antibody to PTHRP (PTHLH) (aa77-126) from mouse. It is reactive with human, mouse, rat and other species. Validated for IHC and WB. Cited in 1 publication. (1) Publication (s) thc tropfen apotheke
MABC532 Sigma-Aldrich Anti-PTHrP Antibody, clone 4C4.1
WebAnti-PTHrP Antibody Products. Listed below are anti-PTHrP antibodies from multiple suppliers. PTHrP is a reported alias name for the human gene PTHLH, or 'parathyroid hormone like hormone'. The 177-amino acid protein is a member of the Parathyroid hormone family. The cellular localization is predicted to be cytoplasmic, nuclear and secreted. WebJun 8, 2024 · Parathyroid hormone–related protein (PTHrP, gene name Pthlh) is a pleiotropic regulator of tissue homeostasis.In bone, Dmp1Cre-targeted PTHrP deletion in osteocytes causes osteopenia and impaired cortical strength.We report here that this outcome depends on parental genotype. In contrast to our previous report using mice … WebWhole exome sequencing (WES) revealed "a novel heterozygous A>G change at nucleotide -3 up-stream of PTHLH exon 3 that encodes the last two amino acids of the pro-sequence and the mature PTHrP...[resulting in] a heterozygous insertion of genomic nucleotides -2 and -1 causing a frame-shift after residue 34 of the preprosequence and thus 29 novel ... thctx