Hoat3
Nettet1. des. 2014 · Using stably transfected cell systems that express the uptake transporters human embryonic kidney (HEK)-hOAT1 and HEK-hOAT3, we analyzed the inhibitory … Nettet1. mai 2001 · A cDNA encoding a multispecific organic anion transporter 3 (hOAT3) was isolated from a human kidney cDNA library. The hOAT3 cDNA consisted of 2179 base pairs that encoded a 543-amino-acid residue protein with 12 putative transmembrane domains. The deduced amino acid sequence of hOAT3 showed 36 to 51% identity to …
Hoat3
Did you know?
Nettet11. Is HotA compatible with the High Definition modification for HoMM III (HD-mod)? HotA is fully compatible with HD-mod and is proven to work correctly under any settings. The … NettetIn this study, the time-dependent inhibition (TDI) of hOAT1 and hOAT3 by anthraquinones was investigated. Madin–Darby canine kidney (MDCK)-hOAT1, HEK293-hOAT3 and their parental cells were used. Preincubation with chrysophanol or physcion for 30 min significantly increased the inhibition of hOAT1, but preincubation with rhein, emodin, …
Nettet1. nov. 2005 · We examined the substrate specificity of human organic anion transporter (hOAT) 1 and hOAT3 for various cephalosporin antibiotics, cephaloridine, cefdinir, cefotiam, ceftibuten, cefaclor ... Nettet2. nov. 2013 · PCS is a substrate for hOAT1 and hOAT3, and hOAT1 and hOAT3 appear to play a physiological role as a high-capacity PCS transporter. Since hOATs are expressed not only in the kidneys, but also in blood vessels and osteoblasts, etc., these findings are of great significance in terms of elucidating the renal clearance, tissue …
Nettet1. nov. 2004 · Human organic anion transporters hOAT1 (SLC22A6) and hOAT3 (SLC22A8) are responsible for renal tubular secretion of an antifolic acid methotrexate, … Nettet17. sep. 2013 · Pemetrexed and methotrexate transport by hOAT3 was saturated at high concentrations with apparent Km values 28.2 µM and 76.6 µM, respectively. In addition, intrinsic activity (Vmax/Km) of ...
Nettet13. jul. 2009 · Previously, we have found that the transport activities of hOAT1 and hOAT3 for perfluorooctanoic acid were nearly equal to those for PAH which is a good substrate for both OAT1 and OAT3 . Therefore, hOAT1 and hOAT3 could involve in perfluorooctanoic acid transport from serum to tubular epithelial through the basolateral membrane, while …
NettetHuman organic anion transporter 3 (hOAT3/SLC22A8) is predominantly expressed in the proximal tubules of the kidney and plays a major role in the urinary excretion of a … network 2 computers ethernetNettetRESULTS: hOAT3-mediated efflux of glutarate (GA), can be significantly trans-stimulated by a variety of ions with high cis-inhibitory potency, including GA (282%), alpha … network 2 computers windows 11NettetToxins 2010, 2 2056 1. Specific Renal Vulnerability A variety of pathogenic mechanisms play a role in drug-induced nephrotoxicity, including hemodynamic changes, glomerular disease, interstitial nephritis, direct cytotoxicity which may result network2.construction.comNettetUeo, H., et al., Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol, 2005. 70(7): p. 1104-13. TranSelect™ Cryopreserved Cells SB-TranSelect-OAT3; PREDICELL™ Kits SB-OAT3-PREDICELL™ UT-96w Kit; network 2 coorparooNettet17. sep. 2013 · When HEK-hOAT3 and -hOAT1 cells were incubated with 100 µM pemetrexed for 30 min, pemetrexed was accumulated at 14- and 1.7-fold greater than that in control cells, respectively. Pemetrexed and methotrexate transport by hOAT3 was saturated at high concentrations with apparent Km values 28.2 µM and 76.6 µM, … i\\u0027m the waterboyNettetIn addition to the transport of p-aminohippurate and estrone sulfate, that of antifolates and antivirals was inhibited by caffeic acid. These findings show that caffeic acid has … network2 constructionNettet18. aug. 2011 · UnityWeb fusion-2.x.x2.5.5b4 ‘@ Q jô ‘]€ôj gþ¨è § »³ú‹_% Ç ðVóux»Õ„© úýÝ ï(:–iBLmʼn I 8‚Æó¼ ŒµÜŽ† Ô¼P (d‡ïê³ëÔ1 ... network 2 home computers use programs