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Study to Evaluate CCS1477 in Haematological Malignancies
WebOct 6, 2024 · Authors. Mohamed Nagy Associate Professor of Endodontics Faculty of Dentistry, Ain Shams University, cairo, Egypt http://orcid.org/0000-0001-9016-1999 ; Ahmed ... WebSep 10, 2024 · CellCentric starts dosing patients in blood cancer trial, expanding clinical testing of CCS1477. CCS1477 is the first drug to be used in patients that specifically targets p300/CBP, offering a new ... please turn your headlights around
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WebDec 12, 2024 · P300 HAT/CREB Binding Protein Inhibitor CCS1477 - Multiple Myeloma Clinical Trials Chemotherapy Protocols MYELOMA CLINICAL TRIALS Multiple Myeloma Patient Education Home Trials FAQ Drugs Centers Events About us More Something Isn’t Working… Refresh the page to try again. Refresh Page Error: … WebCCS-1477 is an inhibitor of p300 and CREB-binding protein (CBP) histone acetyltransferases. It selectively binds to p300 and CBP over bromodomain-containing protein 4 (BRD4, Kds = 1.3, 1.7, and 222 nM, respectively). CCS-1477 inhibits the proliferation of OPM-2 multiple myeloma cells (GI50 = 5 nM). It induces tumor regression … WebCCS-1477 is an inhibitor of p300 and CREB-binding protein (CBP) histone acetyltransferases.1 It selectively binds to p300 and CBP over bromodomain-containing protein 4 (BRD4; K ds = 1.3, 1.7, and 222 nM, respectively). CCS-1477 inhibits the proliferation of OPM-2 multiple myeloma cells (GI prince of peace lutheran church appleton wi